Di episode pertama season 8 ini Cristina (Sandra Oh) dan Meredith (Ellen Pompeo) masih belum berbaikan dengan suami masing-masing. Keduanya bergantian merawat Zola, sementara Derek (Patrick Dempsey) dibantu Owen (Kevin McKidd) sibuk membangun rumah impian Derek. Sebagai akibat dari tindakannya menukar hasil percobaan untuk menolong Adele (Loretta Devine) maka Meredith pun diberhentikan dari pekerjaannya. Cristina pun menyalahkan Alex (Justin Chambers) yang melaporkan Meredith sehingga sahabatnya itu dipecat. Miranda (Chandra Wilson) pun turun tangan melerai Cristina yang menyerang Alex, setelah April (Sarah Drew) gagal menengahi pertengkaran mereka. Sementara itu, Meredith bicara pada Owen untuk membantu suami sahabatnya itu memahami apa yang tengah dialami Cristina.
Setelah terjadi gempa bumi, pasangan suami-isteri, Denny dan Susanah yang sudah bertengkar sejak meninggalkan rumah terpaksa menghentikan pertengkaran mereka. Karena Susanah terperosok ke bawah dan terjebak di sana, Owen terpaksa memandu Denny untuk menolong isterinya.
Daya tarik serial ini masih terletak pada dialognya yang inspiratif dan sedikit filosofis. Berikut beberapa di antaranya :
Meredith: Nobody gets married thinking it’s gonna fail. You think yours is the one that’s gonna make it. And so it always comes as a shock the moment when you realize, it’s over. One minute you’re standing on solid ground. The next minute you’re not.
Meredith: Maybe getting fired was a good thing. What do you cheerful people say when something crappy happens and they make it sound like it wasn’t crappy?
Cristina: A blessing in disguise?
Meredith: Yeah. Maybe that’s what this is. This is that and I can make jam and drive car pool and have playgroups. And maybe that’s enough. And maybe I’ll be a great mom.
Cristina: Ok. Ok. I’m gonna vomit. Uh call me when Meredith comes back.
Meredith: And maybe you want to be a mom, too, and that’s why you can’t go through with it.
Cristina: I wish I wanted a kid. I wish I wanted one so bad, cause then this would be easy. I would be happy. I’d have Owen, and my life wouldn’t be a mess. But I don’t. I don’t want a kid. I mean, I don’t want to make jam. I, I don’t want to car pool. I really, really, really don’t want to be a mother. I want to be a surgeon, and plese get it. I need someone to get it. And I wish that someone was Owen. I wish that that… that at any minute, he’ll get it and show up for me, but that’s not gonna happen. And you’re my person. I need you to be there at 6.00 tonight to hold my hand, cause I am scared, Mer, and sad, cause my husband doesn’t get that. So I need you to.
Meredith: Ok, do you know what will happen to Cristina if she has a kid that she doesn’t want? It will almost kill her. Trying to pretend that she loves a kid as much as she loves surgery will almost kill her, and it’ll almost kill your kid. Do you know what it’s like to be raised by someone who didn’t want you? I do. To know you stood in the way of your mother’s career? I do. I was raised by a Cristina. My mother was a Cristina. And as the child she didn’t want, I am telling you, don’t do this to her, because she kind and she cares, and she won’t make it. The guilt of resenting her own kid will eat her alive.
Meredith: Do you have what it takes? If your marriage is in trouble, can you weather the storm? When the ground gives way and your world collapses maybe you just need to have faith and trust that you can survive this together. Maybe you just need to hold on tight and no matter what, don’t let go.